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mRNAs – The drivers of pathology

mRNAs and Metabolic Diseases

mRNAs (messenger RNAs) are short-lived molecules, that act as transmitters of genetic information in gene expression and control physiological activities in the human body. Among their many functions in the human body is the modulation of the metabolic activity of the subcutaneous adipose tissue (SAT). For sustaining a healthy and functional (energy) metabolism of the SAT a set of mRNAs need to interact within certain corridors. Any disbalance in the mRNA-expressions, i.e., relative over- or under-expressions, can lead to dysfunctions in the energy metabolism of the SAT.

Our Approach

We focus on clusters of specific mRNAs which are central in controlling and moderating the dynamics of functional SAT. The core-cluster, which can be expanded to cover more diseases dynamics, is involved in the functionality of the energy metabolism of the SAT. Disbalances in the mRNA-expressions of this core-cluster have an essential biological impact on the development of metabolic diseases. The pivotal influence of our mRNA-cluster on the development of metabolic diseases has been demonstrated in several studies.

Medical Utilisation of our mRNAs

Reading our target mRNAs enables a direct analysis of present metabolic activities and dynamics. They give precise information on the current functional state of the adipose tissue of a patient. They are a highly valuable source for diagnostics.

Influencing the composition of our target mRNAs and controlling their quantity are strong levers for restoring a functional energy metabolism. Rebalancing unhealthy mRNA-patterns opens up a whole new approach for therapeutic intervention with pathogenic metabolic processes.

As our targeted mRNAs are involved in the genesis of diseases they can be detected long before any symptoms or metabolites of these diseases can be diagnosed by a blood draw.  Therefore, they are a superior instrument for very early diagnosis for prevention.

Breaking new ground for
diagnostics, therapeutics and prevention

Diagnostics

mRNA-analysis of the SAT offers deep and completely new insights into the energy metabolism. Especially with metabolic diseases the current dynamics of the body and influences over life-time play a far greater role than genetic dispositions

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Therapeutics

The key to successful treatment of metabolic diseases lies in the intervention with disease-causing on-going biological processes. As the mRNA of the SAT are to a great extent the drivers of pathology of these diseases, they offer a strong lever for therapy.

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Prevention

A great advantage of mRNA-analysis of the subcutaneous adipose tissue lies in the very early detection of unhealthy developments of the metabolism long before any signs can be seen in blood-analysis or any symptoms become apparent. It is, therefore, a powerful component in preventive personalised medicine.

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