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Our mRNA panel

The core panel of the Lipocyte BioMed includes the mRNAs regarding: HMGA2, PPARG, ADIPOQ and IL-6. It can be supplemented with additional mRNAs if necessary.

HMGA2

HMGA2 (High Mobility Group AT-hook 2) is a transcription factor influencing the regulation of gene expressions and belonging to the group of high-mobility group-A proteins. As an architectural transcription factor, it increases or inhibits the binding ability of other transcription factors via structural changes in chromatin organization. The HMGA2 protein plays an important role in biological processes, such as growth, reproduction and differentiation.

PPARG

PPARG (peroxisome proliferator-activated receptor gamma) is a ligand-binding nuclear transcription factor of the PPAR subfamily, belonging to the group of nuclear hormone receptors. PPAR-gamma activates the transcription of various genes by heterodimerization using the retinoid X receptor α (RXRα).

ADIPOQ

ADIPOQ (Adiponectin, C1Q and collagen domain containing) encodes adiponectin, which plays an important role in glucose regulation and fatty acid oxidation. It promotes metabolic health, including inducing fatty acid oxidation in the liver, suppressing glucose production in the liver, improving β-cell function, and increasing peripheral insulin sensitivity.

IL-6

IL-6 (interleukin 6) is a cytokine that plays a role in both inflammatory responses and the maturation of B lymphocytes. About one-third of the IL-6 circulating in blood plasma comes from adipose tissue. The amount of IL-6 in plasma correlates positively with obesity, i.e. higher concentrations of IL-6 are usually found in the plasma of obese people. Increased secretion of IL-6 in obesity contributes to metabolic dysfunction.

We unlock the treasure trove of the adipose tissue

Subcutaneous adipose tissue (SAT)

The subcutaneous adipose tissue (SAT) plays an important role in the genesis and modulation of metabolic diseases. It offers new opportunities for personalised medicine.

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mRNAs are a key to personalised medicine

mRNAs (messenger RNAs)

mRNAs (messenger RNAs) convey genetic information in the body. They are highly involved in modulating metabolic processes, especially processes of the energy metabolism. Wit metabolic diseases they can be seen as drivers of pathology.

mRNAs – The drivers of pathology

Breaking new ground for
diagnostics, therapeutics and prevention

Diagnostics

mRNA-analysis of the SAT offers deep and completely new insights into the energy metabolism. Especially with metabolic diseases the current dynamics of the body and influences over life-time play a far greater role than genetic dispositions

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Therapeutics

The key to successful treatment of metabolic diseases lies in the intervention with disease-causing on-going biological processes. As the mRNA of the SAT are to a great extent the drivers of pathology of these diseases, they offer a strong lever for therapy.

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Prevention

A great advantage of mRNA-analysis of the subcutaneous adipose tissue lies in the very early detection of unhealthy developments of the metabolism long before any signs can be seen in blood-analysis or any symptoms become apparent. It is, therefore, a powerful component in preventive personalised medicine.

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