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Prevention: Disease screening based on a SAT draw

The Challenge

Metabolic diseases build up over long periods of time. During this initial phase the body starts adapting to the dysfunctions in energy metabolism and develops physiological deficiencies which ultimately lead to the outbreak of the disease. An example is the build-up of insulin-resistant adipose tissue which needs years to develop.

Similar problems occur with obesity related cancers which are very often only detected when they have reached a significant stage.

Our Goal

The analysis of mRNA in the subcutaneous adipose tissue (SAT) offers completely new opportunities for very early detection of metabolic diseases and some obesity related cancers. mRNAs of the SAT are highly involved in the genesis of these diseases. Unhealthy and potentially disease triggering developments can be seen in mRNA-patterns long before (years before) any characteristics or markers can be found in the blood.

Integrating a wide range of tests in a comprehensive screening analysis allows for easy and simple identification of patient-individual metabolic risks. The content of the screening will encompass a wide range of metabolic diseases and will continuously be expanded.

Breaking new ground for
diagnostics, therapeutics and prevention


mRNA-analysis of the SAT offers deep and completely new insights into the energy metabolism. Especially with metabolic diseases the current dynamics of the body and influences over life-time play a far greater role than genetic dispositions

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The key to successful treatment of metabolic diseases lies in the intervention with disease-causing on-going biological processes. As the mRNA of the SAT are to a great extent the drivers of pathology of these diseases, they offer a strong lever for therapy.

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A great advantage of mRNA-analysis of the subcutaneous adipose tissue lies in the very early detection of unhealthy developments of the metabolism long before any signs can be seen in blood-analysis or any symptoms become apparent. It is, therefore, a powerful component in preventive personalised medicine.

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